Lasers slim down radiotherapy equipment

Hospitals could benefit from a new technique that uses ultra-short laser pulses to simplify radiotherapy equipment.

via www.optics.org

Researchers from Italy, France and Germany have shown that a tabletop laser can be used to accelerate a beam of electrons suitable for use in radiotherapy. The group, led by Antonio Giulietti of the Institute for Physical Chemistry Processes in Pisa, believes that such laser-based particle acceleration could considerably reduce the size and simplify the operation of radiotherapy facilities (Physical Review Letters 101 105002).

In radiotherapy beams of photons, electrons, protons, neutrons or ions are used to destroy tumours by ionizing the atoms within the tumours' DNA. Usually this involves irradiating the patient from a number of different directions in order to pinpoint the tumour, and in the case of deep tumours, using higher-energy particles. This inevitably leads to some damage of the healthy tissue surrounding the tumour.

Damage limitation

Damage can be limited using a technique known as intraoperatory radiotherapy (IORT), which involves irradiating the patient just once with electrons. This occurs in the operating theatre right after the tumour has been surgically removed. The idea is to destroy tumour cells that the surgery has missed. Because they do not have to penetrate deeply, the electrons can be fewer in number and have a lower energy, which means that the accelerators employed can be smaller.

However, as Giulietti points out, IORT, like ordinary radiotherapy, still uses radiofrequency electric fields to accelerate the electrons, which requires a machine more than two metres high and over half a tonne in weight. The machine must be shielded from the operating theatre and any maintenance requires the shut down of the theatre. "This therefore limits the energy of the electrons that can be used in the technique," he adds.

Giulietti and colleagues have shown that these problems can be overcome by using a laser rather than radiofrequency electric fields to accelerate the electrons.

At the SLIC laboratory in Saclay, France, the researchers fired ultra-short laser pulses onto a jet of gas, creating a plasma with a fluctuating electron density. The electric field generated by these fluctuations accelerated the free electrons within the plasma such that they had energies and spatial characteristics suitable for use in IORT. By then passing these electrons through a 2 mm–thick piece of tantalum (and therefore decelerating them rapidly) the researchers were able to create gamma–ray photons that could also be used in radiotherapy.

Just a small metal box

Because the laser beam can travel for several tens of metres without any appreciable loss, the laser itself can be located outside the operating theatre. According to Giulietti, the only thing that would need to be in the theatre is a metallic box perhaps 50 by 20 by 20 cm across that would convert the laser beam into the electron beam, and which would contain a roughly 10 cm–long device to generate the gas jet and focusing optics of a similar size.

Giulietti points out that scaling up the facility would allow IORT to be carried out at higher energies than is currently possible, which would render the technique more effective against certain kinds of tumours. He adds that more work is needed to design a laser–based system suitable for actual hospital use, in particular ensuring the stability of both the laser output and the acceleration process within the plasma.

Generation of intense continuum EUVradiation by many-cycle laser fields

The scientists at Institute of Electronic Structure & Laser in Greece and Max-Planck-Institut für Quantenoptik in Germany reported their research results in recent issue of Nature Physics.

Continuing efforts in ultrashort pulse engineering have recently led to the breakthroughs of the generation of attosecond (10^-18 s) pulse trains and isolated pulses. Although trains of multiple pulses can be generated through the interaction of many-optical-cycle pulses with gases—a process that has led to intense extreme-ultraviolet emission—the generation of isolated high-intensity pulses, which requires few-cycle driving pulses, remains a challenge. Here, we report a vital step towards the generation of such pulses, the production of broad continuum extreme-ultraviolet emission using a high-intensity, many-cycle, infrared pulsed laser, through the interferometric modulation of the ellipticity of 50-fs-long driving pulses. The increasing availability of high-power many-cycle lasers and their potential use in the construction of intense attosecond radiation—with either gas or solid-surface targets—offer exciting opportunities for multiphoton extreme-ultraviolet-pump–extreme-ultraviolet-probe studies of laser–matter and laser–plasma interactions.

The Dual Michelson interferometer device is shown in the left picture, BS: beam splitters. M: flat mirrors. TS1,2,3: piezoelectric translation stages. A: intensity attenuator. First and second MI: first and second Michelson interferometers.

Laser-generated radiation for cancer therapy?

Will laser-generated radiation one day prove useful in cancer therapy? A UK collaboration aims to find out. Reported from oprtics.org:

A consortium of UK-based scientists has secured £5 million ($9.9 million) in research funding to turn the concept of laser-generated radiation into a robust, ready-to-go technology. The four-year project, involving researchers from nine separate institutions, could lead to cheaper, simpler solutions for proton and ion radiotherapy. Laser-energized radiation sources could also cut the cost of research into cosmic-radiation exposure from frequent air travel and manned space missions.

The project named LIBRA, which means Laser Induced Beams of Radiation and their Applications. Development of the technology will require access to a very high-powered laser with a rapid-fire repetition rate. One such system is the GEMINI laser, due to come on-line at the Rutherford Appleton Laboratory (RAL) near Oxford, UK, later this year. GEMINI is expected to deliver 1 PW (10^15 W) pulses every 20 seconds.

related links: LIBRA, GEMINI